Evaluation of the associations between GDF-15, OPG, and IL-15 levels in CRC: preliminary results

Introduction: Osteoprotegerin (OPG), Interleukin-15 (IL-15), and Growth/Differentiation Factor-15 (GDF-15) are all proven to take part in the processes associated with colorectal carcinoma (CRC) including tissue remodeling, inflammation modulation, metastasis. Aim of study: To investigate concentrations GDF-15, OPG IL-15 tumor margin tissues CRC relation clinicopathological features patients. Material methods: The study used 50 specimens tumor-free obtained from determine commercially available enzyme-linked immunosorbent assay (ELISA) kits were used. Results: Concentrations significantly higher comparison margin. levels GDF-15 positively those IL-15, while correlated IL-15. There was no association between investigated molecules clinical Conclusions: elevated patients suffering CRC. More studies needed establish a specific role these cytokines development, growth, progression, prognosis examine their as possible treatment candidates.